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Greater celandine (Chelidonium majus)



Interactions

Greater celandine/Drug Interactions:
  • Antidepressant agents, monoamine oxidase inhibitors (MAOIs)Antidepressant agents, monoamine oxidase inhibitors (MAOIs): The major alkaloids from plants such as greater celandine and drugs such as "UkrainT" (thiophosphoric acid derivative of a sum of the alkaloids isolated from greater celandine) have been shown to be irreversible inhibitors of the oxidative deamination reaction of serotonin and tyramine catalyzed by rat liver mitochondrial monoamine oxidase (MAO) (8). Chelironine and the drug UkrainT were the strongest inhibitors of the reaction among the agents studied.
  • Antidepressants, selective serotonin reuptake inhibitors (SSRIs)Antidepressants, selective serotonin reuptake inhibitors (SSRIs): Research with intraperitoneal administration of UkrainT in rats has shown that one of the primary actions of UkrainT involves inhibition of the serotonergic system (7).
  • Antidiabetic agentsAntidiabetic agents: Greater celandine has traditionally been used for the treatment of diabetes; however, administration of dried leaves of celandine (6.25% of diet by weight) to streptozotocin induced diabetic rats did not affect the development of hyperphagia polydipsia, body weight loss, hyperglycemia, and hypoinsulinemia (22).
  • Anti-inflammatoriesAnti-inflammatories: Based on laboratory study, stylopine, a major constituent of Chelidonium majus L. leaf, suppresses nitrous oxide (NO) and prostaglandin E2 (PGE2) production in macrophages by inhibiting the iNOS and COX-2 expressions (27). These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus. It has also been proposed that quaternary benzophenanthridine alkaloids from Chelidonium majus may play a role in the anti-inflammatory activity (10).
  • Antineoplastic agentsAntineoplastic agents: In patients with advanced esophageal cancer, the combination of Chelidonium majus L. and endoxan appeared to mask the immunological response of the host without instigating the degeneration of cancer tissue seen in patients who took Chelidoniummajus alone (48).
  • Antiretroviral agentsAntiretroviral agents: A substance isolated from the freshly prepared crude extract of Chelidonium majus L. has been shown to have antiretroviral activity against HIV-1 in vitro (64).
  • Antiulcer agentsAntiulcer agents: Based on animal study, Chelidonium majus extract alone and in a combination with extracts from the plants Iberis amara, Melissa officinalis, Matricaria recutita, Carum carvi, Mentha x piperita, Glycyrrhiza glabra, Angelica archangelica, and Silybum marianum (STW 5 - Iberogast®) produced a dose dependent anti-ulcerogenic activity against indometacin induced gastric ulcers in rats (31).
  • Apoptosis agentsApoptosis agents: In in vitro research, UkrainT induced apoptosis in a panel of cancer cell lines (including HeLa cervical cancer cells) through activation of the intrinsic cell death pathway (65).
  • Biliary pain agentsBiliary pain agents: In a prospective multicenter pilot study, Cholagogum F Nattermann® (dried extracts of Scholkraut and Curcuma) reduced right upper quadrant colicky pain more effectively than placebo in 76 patients with biliary dyskinesia (1).
  • BisphosphonatesBisphosphonates: UkrainT may have antiosteoporotic effects because of its "anabolic effect" on bone in ovariectomized rats. The proposed mechanism of action in this regard is a stimulating effect on gonadal hormone production, especially estrogen. However, the data on UkrainT's effects on bone metabolism is conflicting (3; 4; 5; 6).
  • CNS depressantsCNS depressants: In rats and mice, intraperitoneal administration of UkrainT potentiated the action of hexobarbital. In rats, intraperitoneal administration of UkrainT potentiated the action of amphetamine and apomorphine, but did not affect the action of haloperidol (7).
  • CNS stimulantsCNS stimulants: In rats and mice, intraperitoneal administration of UkrainT potentiated the action of hexobarbital. In rats, intraperitoneal administration of UkrainT potentiated the action of amphetamine and apomorphine, but did not effect the action of haloperidol (7).
  • Cytotoxic agentsCytotoxic agents: UkrainT exhibits toxicity toward malignant cells. Some experts have presented evidence that UkrainT is equally toxic to normal, transformed, and malignant cell lines (39; 36).
  • Treatment of peritoneal exudates macrophages from tumor bearing mice with Ukrain restored their defective cytolytic response against DA-3 tumor cells. This data suggests that the in vivo anti-tumor effects of Ukrain may be due in part it its ability to restore the cytolytic function of macrophages (57).
  • Dopamine agonistsDopamine agonists: Research with intraperitoneal administration of UkrainT in rats has shown that one of the primary actions of UkrainT involves stimulation of the dopaminergic system (7).
  • Dopamine antagonistsDopamine antagonists: Research with intraperitoneal administration of UkrainT in rats has shown that one of the primary actions of UkrainT involves stimulation of the dopaminergic system (7).
  • ImmunomodulatorsImmunomodulators: The immunomodulating effects of UkrainT include improvements in total T-cell, T-helper cell, and NK-cells counts, a decrease in T-suppressor cells, and a normalizing of the H/S ratio in cancer patients (40; 38).
  • Interferon gammaInterferon gamma: In in vitro research, the combination of greater celandine and recombinant interferon-gamma (rIFN-gamma) resulted in a marked cooperative induction of nitrous oxide (NO) production and a significant increase in tumor necrosis factor-alpha (TNF-alpha) in mouse peritoneal macrophages (12).
  • Osteoporosis agentsOsteoporosis agents: UkrainT, administered intraperitoneally at doses of 7 or 14mg/kg (every other day for 10 days, followed by a 10-day break, for five cycles), resulted in decreased bone mineral density in ovariectomized rats, as assessed by the dual-energy X-ray absorptiometry (DXA) densitometric method (60). In theory, greater celandine or UkrainT may interact with osteoporosis agents.
  • Serotonin receptor antagonistsSerotonin receptor antagonists: Research with intraperitoneal administration of UkrainT in rats has shown that one of the primary actions of UkrainT involves inhibition of the serotonergic system (7).

Greater celandine/Herb/Supplement Interactions:
  • Antidepressant agents, monoamine oxidase inhibitors (MAOIs)Antidepressant agents, monoamine oxidase inhibitors (MAOIs): The major alkaloids from plants such as greater celandine and drugs such as "UkrainT" (thiophosphoric acid derivative of a sum of the alkaloids isolated from greater celandine) have been shown to be irreversible inhibitors of the oxidative deamination reaction of serotonin and tyramine catalyzed by rat liver mitochondrial monoamine oxidase (MAO) (8). Chelironine and the drug UkrainT were the strongest inhibitors of the reaction among the agents studied.
  • Antidepressants, selective serotonin reuptake inhibitors (SSRIs)Antidepressants, selective serotonin reuptake inhibitors (SSRIs): Research with intraperitoneal administration of UkrainT in rats has shown that one of the primary actions of UkrainT involves inhibition of the serotonergic system (7).
  • Anti-inflammatoriesAnti-inflammatories: Based on laboratory study, stylopine, a major constituent of Chelidonium majus L. leaf, suppresses nitrous oxide (NO) and prostaglandin E2 (PGE2) production in macrophages by inhibiting the iNOS and COX-2 expressions (27). These biological activities of stylopine may contribute to the anti-inflammatory activity of Chelidonium majus. It has also been proposed that quaternary benzophenanthridine alkaloids from Chelidonium majus may play a role in the anti-inflammatory activity (10).
  • AntineoplasticsAntineoplastics: UkrainT exhibits toxicity toward malignant cells. Some experts have presented evidence that UkrainT is equally toxic to normal, transformed, and malignant cell lines (39; 36; 48). In theory, greater celandine or UkrainT may have additive effects with herbs with potential anticancer effects.
  • Antiulcer agentsAntiulcer agents: Based on animal study, Chelidonium majus extract alone and in a combination with extracts from the plants Iberis amara, Melissa officinalis, Matricaria recutita, Carum carvi, Mentha x piperita, Glycyrrhiza glabra, Angelica archangelica, and Silybum marianum (STW 5 (Iberogast®) produced a dose dependent anti-ulcerogenic activity against indometacin induced gastric ulcers in rats (31).
  • AntiviralsAntivirals: A substance isolated from the freshly prepared crude extract of Chelidonium majus L. has been shown to have antiretroviral activity against HIV-1 in vitro (64).
  • Biliary pain agentsBiliary pain agents: In a prospective multicenter pilot study Cholagogum F Nattermann® (dried extracts of Scholkraut and Curcuma) reduced right upper quadrant colicky pain more effectively than placebo in 76 patients with biliary dyskinesia (1).
  • CNS agentsCNS agents: In rats and mice, intraperitoneal administration of UkrainT potentiated the action of hexobarbital. In rats, intraperitoneal administration of UkrainT potentiated the action of amphetamine and apomorphine, but did not effect the action of haloperidol (7).
  • Dopaminergic agentsDopaminergic agents: Research with intraperitoneal administration of UkrainT in rats has shown that one of the primary actions of UkrainT involves stimulation of the dopaminergic system (7).
  • HypoglycemicsHypoglycemics: Greater celandine has traditionally been used for the treatment of diabetes; however, administration of dried leaves of celandine (6.25% of diet by weight) to streptozotocin induced diabetic rats did not affect the development of hyperphagia polydipsia, body weight loss, hyperglycemia, or hypoinsulinemia (22).
  • ImmunomodulatorsImmunomodulators: The immunomodulating effects of UkrainT include improvements in total T-cell, T-helper cell, and NK-cells counts, a decrease in T-suppressor cells, and a normalizing of the H/S ratio in cancer patients (40; 38).
  • Osteoporosis agentsOsteoporosis agents: UkrainT, administered intraperitoneally at doses of 7 or 14mg/kg (every other day for 10 days, followed by a 10-day break, for five cycles), resulted in decreased bone mineral density in ovariectomized rats, as assessed by the dual-energy X-ray absorptiometry (DXA) densitometric method (60). In theory, greater celandine or UkrainT may interact with herbs with effects on bone density.
  • TurmericTurmeric: Several weeks after ingesting a combination herbal preparation containing greater celandine (Chelidonium majus) and curcuma root, a 42 year-old woman developed jaundice due to acute hepatitis (30). Her clinical recovery was rapid after withdrawal of the medication, and within two months her hepatic functions had returned to normal. This report raises the question of a possible interaction between greater celandine and curcuma root; however, causality remains unclear.

Greater celandine/Food Interactions:
  • Insufficient available evidence.

Greater celandine/Lab Interactions:
  • AlbuminAlbumin: UkrainT has been shown to lower the anti-ovalbumin IgE antibody response and decrease antigen-induced histamine release from mast cells in ovalbumin (OA) sensitized mice (66).
  • Body weightBody weight: Treatment with UkrainT in ovariectomized rats resulted in an increase in body weight (61).
  • Bone densityBone density: UkrainT, administered intraperitoneally at doses of 7 or 14mg/kg (every other day for 10 days, followed by a 10-day break, for five cycles), resulted in decreased bone mineral density in ovariectomized rats, as assessed by the dual-energy X-ray absorptiometry (DXA) densitometric method (60).
  • Immune systemImmune system: The immunomodulating effects of UkrainT include improvements in total T-cell, T-helper cell, and NK-cells counts, a decrease in T-suppressor cells, and a normalizing of the H/S ratio (40; 38).
  • Serum glucose levelsSerum glucose levels: Greater celandine has traditionally been used for the treatment of diabetes; however, administration of dried leaves of celandine (6.25% of diet by weight) to streptozotocin induced diabetic rats did not affect the development of hyperphagia polydipsia, body weight loss, hyperglycemia, or hypoinsulinemia (22).

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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