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Fig (Ficus carica L.)

Image

Also listed as: Ficus carica L.
Related terms
Background
Evidencetable
Tradition
Dosing
Safety
Interactions
Attribution
Bibliography

Related Terms
  • Caricae fructus, feigen, Ficus benjamina (weeping fig), Ficus carica, Ficus elastica (rubber plant).

Background
  • Figs are thought to have been first cultivated in Egypt. They spread to ancient Crete and subsequently, to ancient Greece where they became a staple in the traditional diet. Figs were regarded with such esteem that laws were created forbidding the export of the best quality figs. Figs were respected in ancient Rome and thought of as a sacred fruit. According to Roman myth, the twin founders of Rome, Romulus and Remus, rested under a fig tree.
  • Traditionally, figs have been used to treat constipation, bronchitis, high cholesterol, eczema, psoriasis (chronic skin disease), vitiligo (white skin patches), and diabetes (high blood sugar). Topically, its latex has been used to remove warts and treat skin tumors.
  • At this time, there are no high quality human trials supporting the effectiveness of fig for any indication. However, the antioxidant activity and cytotoxicity against various cancer cell lines reported in fig are potentially promising in its future therapeutic uses.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Early evidence suggests that fig has antioxidant properties and may be beneficial in type 1 diabetes. Additional study is warranted in this area.

C
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)


Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

  • Antioxidant, cancer, hemostatic potency (stops bleeding), photosensitization (abnormal sensitivity to sunlight).

Dosing

Adults (18 years and older)

  • There is no proven safe or effective dose for fig. However, as a tea decoction, 1 cup daily of 13 grams of Ficus carica leaf has been used.

Children (younger than 18 years)

  • There is no proven safe or effective dose for fig in children and use if not recommended.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

  • Avoid in individuals with a known allergy or hypersensitivity to fig or herbs in the Moraceae family. Some oral allergy syndromes have been attributed to the cross-sensitivity in people to grass and birch pollens. Food allergy to fig has also been reported due to cross sensitization to weeping fig (Ficus benjamina), or mulberry. Sensitization to fig with cross-sensitization to weeping fig and natural rubber latex has also been reported.
  • Allergic reactions to fresh or dried figs can present as a consequence of primary sensitization to airborne Ficus benjamina allergens independent of sensitization to rubber latex allergens. Kiwi fruit, papaya, and avocado as well as pineapple and banana may be other fruits associated with sensitization to Ficus allergens.

Side Effects and Warnings

  • There are few reports of adverse effects associated with fig. At least one report has indicated no adverse effects in subjects who were treated with an oral (by mouth) fig leaf decoction for one month. However, because fig leaf contains psoralens, it may cause photodermatitis when applied on the skin. Excessive sunlight or ultraviolet light exposure should be avoided while using products that contain fig leaf.
  • Many cases of occupational allergy to weeping fig in plant keepers have been reported and side effects may include conjunctivitis, rhinitis, anaphylactic shock or asthma.
  • Although rare, obstructive ileus (intestinal/bowel obstruction), hemolytic anemia (deficiency of red blood cells), and retinal hemorrhages (bleeding of the retina) have been reported. Use cautiously in patients with bleeding disorders.

Pregnancy and Breastfeeding

  • Fig, taken as a medicinal agent, is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence. However, fresh or dried fruit is likely safe when taken by mouth in amounts commonly found in foods.

Interactions

Interactions with Drugs

  • Theoretically, because fig leaf contains furocoumarins, it may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
  • Theoretically, fig leaf may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Interactions with Herbs and Dietary Supplements

  • Theoretically, because fig leaf contains furocoumarins, it may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
  • Theoretically, fig leaf may lower blood sugar levels. Caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Attribution
  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography
  1. Anahory T, Darbas H, Ongaro O, et al. Serratia ficaria: a misidentified or unidentified rare cause of human infections in fig tree culture zones. J Clin Microbiol 1998;36(11):3266-3272.
  2. Antico A, Zoccatelli G, Marcotulli C, et al. Oral allergy syndrome to fig. Int Arch Allergy Immunol 2003;131(2):138-142.
  3. Bollero D, Stella M, Rivolin A, et al. Fig leaf tanning lotion and sun-related burns: case reports. Burns 2001;27(7):777-779.
  4. Brehler R, Abrams E, Sedlmayr S. Cross-reactivity between Ficus benjamina (weeping fig) and natural rubber latex. Allergy 1998;53(4):402-406.
  5. Caiaffa MF, Cataldo VM, Tursi A, et al. Fig and mulberry cross-allergy. Ann Allergy Asthma Immunol 2003;91(5):493-495.
  6. Diez-Gomez ML, Quirce S, Aragoneses E, et al. Asthma caused by Ficus benjamina latex: evidence of cross-reactivity with fig fruit and papain. Ann Allergy Asthma Immunol 1998;80(1):24-30.
  7. Erdmann SM, Hipler UC, Merk HF, et al. Sensitization to fig with cross-sensitization to weeping fig and natural rubber latex. Int Arch Allergy Immunol 2004;133(3):316.
  8. Focke M, Hemmer W, Wohrl S, et al. Cross-reactivity between Ficus benjamina latex and fig fruit in patients with clinical fig allergy. Clin Exp Allergy 2003;33(7):971-977.
  9. Kanerva L, Estlander T, Petman L, et al. Occupational allergic contact urticaria to yucca (Yucca aloifolia), weeping fig (Ficus benjamina), and spathe flower (Spathiphyllum wallisii). Allergy 2001;56(10):1008-1011.
  10. Ozdamar E, Ozbek S, Akin S. An unusual cause of burn injury: fig leaf decoction used as a remedy for a dermatitis of unknown etiology. J Burn Care Rehabil 2003;24(4):229-233.
  11. Perez C, Canal JR, Torres MD. Experimental diabetes treated with ficus carica extract: effect on oxidative stress parameters. Acta Diabetol 2003;40(1):3-8.
  12. Richter G, Schwarz HP, Dorner F, et al. Activation and inactivation of human factor X by proteases derived from Ficus carica. Br J Haematol 2002;119(4):1042-1051.
  13. Rubnov S, Kashman Y, Rabinowitz R, et al. Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation. J Nat Prod 2001;64(7):993-996.
  14. Serraclara A, Hawkins F, Perez C, et al. Hypoglycemic action of an oral fig-leaf decoction in type-I diabetic patients. Diabetes Res Clin Pract 1998;39(1):19-22.
  15. Werfel S, Rueff F, Przybilla B. [Anaphylactic reaction to Ficus benjamina (weeping fig)]. Hautarzt 2001;52(10 Pt 2):935-937.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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