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Bilberry (Vaccinium myrtillus)

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Also listed as: Vaccinium myrtillus anthocyanoside
Related terms
Background
Evidencetable
Tradition
Dosing
Safety
Interactions
Attribution
Bibliography

Related Terms
  • Airelle, anthocyanins, Bickbeere (German), bilberry leaf, black whortle, Blaubeere (Dutch), blaubessen, bleaberry, blueberry, bogberry, bog bilberry, burren myrtle, cranberry, dwarf bilberry, dyeberry, Ericaceae (family), European blueberry, Heidelbeere (Dutch), Heidelbeereblatter, heidelberry, huckleberry, hurtleberry, lingonberry, lowbush blueberry, Mirtillo nero (Italian), Myrtilli folium, Myrtilli fructus, Myrtilus niger Gilib., Optiberry, resveratrol, sambubiosides, trackleberry, Vaccinium angulosum Dulac, Vaccinium montanum Salibs., Vaccinium myrtillus anthocyanoside extract, VMA extract, VME, whortleberry, wineberry.

Background
  • Bilberry, a close relative of blueberry, has a long history of medicinal use. The dried fruit has been popular for the symptomatic treatment of diarrhea, for topical relief of minor mucus membrane inflammation, and for a variety of eye disorders, including poor night vision, eyestrain, and myopia.
  • Bilberry fruit and its extracts contain a number of biologically active components, including a class of compounds called anthocyanosides. These have been the focus of recent research in Europe.
  • Bilberry extract has been evaluated for efficacy as an antioxidant, mucostimulant, hypoglycemic, anti-inflammatory, "vasoprotectant," and lipid-lowering agent. Although pre-clinical studies have been promising, human data are limited and largely of poor quality. At this time, there is not sufficient evidence in support of (or against) the use of bilberry for most indications. Notably, the evidence suggests a lack of benefit of bilberry for the improvement of night vision.
  • Bilberry is commonly used to make jams, pies, cobblers, syrups, and alcoholic/non-alcoholic beverages. Fruit extracts are used as a coloring agent in wines.

Evidence Table

These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. GRADE *


Bilberry has sometimes been used traditionally to treat heart disease and atherosclerosis. There is some laboratory research in this area, but there is a lack of clear information in humans.

C


Bilberry extract has been used for a number of eye problems, including the prevention of cataract worsening. At this time, there is limited scientific information in this area.

C


Chronic venous insufficiency is a condition that is more commonly diagnosed in Europe than in the United States, and it may include leg swelling, varicose veins, leg pain, itching, and skin ulcers. A standardized extract of bilberry called Vaccinium myrtillius anthocyanoside (VMA) is popular in Europe for the treatment chronic venous insufficiency. However, there is only preliminary research in this area, and more studies are needed before a recommendation can be made.

C


Bilberry has been used traditionally in the treatment of diabetes, and animal research suggests that bilberry leaf extract can lower blood sugar levels. Human research is needed in this area before a recommendation can be made.

C


Bilberry is used traditionally to treat diarrhea, but there is a lack of reliable research in this area.

C


There is limited research suggesting a possible benefit of bilberry in the treatment of fibrocystic disease of the breast. More study is needed before a strong recommendation can be made.

C


High intraocular pressure is considered a risk factor for developing glaucoma. Products containing bilberry may reduce the risk for developing glaucoma. Additional study is needed.

C


Preliminary evidence suggests that bilberry may be helpful for the relief of menstrual pain, although more research is necessary before a firm conclusion can be drawn.

C


Based on animal research and several small human studies, bilberry may be useful in the treatment of retinopathy in patients with diabetes or high blood pressure. However, this research is early, and it is still unclear if bilberry is beneficial for this condition.

C


Bilberry extract has been suggested as a treatment to help stomach ulcer healing. There is some support for this use from laboratory and animal studies, but there is a lack of reliable human evidence in this area.

C


Traditional use and several unclear studies from the 1960s and 1970s suggest possible benefits of bilberry on night vision. However, more recent well-designed studies report no benefits. Based on this evidence, it does not appear that bilberry is helpful for improving night vision.

D
* Key to grades

A: Strong scientific evidence for this use
B: Good scientific evidence for this use
C: Unclear scientific evidence for this use
D: Fair scientific evidence for this use (it may not work)
F: Strong scientific evidence against this use (it likley does not work)


Tradition / Theory

The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

  • Age-related macular degeneration, angina (chest pain), angiogenesis (blood vessel formation), antifungal, antimicrobial, antioxidant, antiseptic, antiviral, arthritis, bleeding gums, burns, cancer, cardiovascular disease, chemoprotectant, chronic fatigue syndrome, common cold, cough, dermatitis, dysentery (severe diarrhea), edema (swelling), encephalitis (tick-borne), eye disorders, fevers, gout (painful inflammation), heart disease, hematuria (blood in the urine), hemorrhoids, high blood pressure, high cholesterol, kidney disease, lactation suppression, laxative (fresh berries), leukemia, liver disease, macular degeneration, oral ulcers, pharyngitis, poor circulation, retinitis pigmentosa, scurvy, skin infections, sore throat, stomach upset, tonic, urine blood, urinary tract infection, varicose veins of pregnancy, vision improvement.

Dosing

Adults (18 years and older)

  • Fresh berries 55 to 115 grams three times daily or 80 to 480 milligrams of aqueous extract three times daily by mouth (standardized to 25% anthocyanosides) have been used traditionally.
  • Dried fruit 4 to 8 grams by mouth with water two times per day has been used traditionally, or decoction of dried fruit by mouth three times per day (made by boiling 5 to 10 grams of crushed dried fruit in 150 milliliters of water for 10 minutes and straining while hot), or cold macerate of dried fruit by mouth three times per day (made by soaking dried crushed fruit in 150 milliliters of water for several hours). Experts have warned that patients should use dried bilberry preparations because the fresh fruit may actually worsen diarrhea.
  • Some experts recommend using a mouthwash gargle of 10% dried fruit decoction as needed for mucus membrane inflammation.

Children (younger than 18 years)

  • There is not enough scientific evidence to recommend the use of bilberry in children.

Safety

The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

Allergies

  • People with allergies to plants in the Ericaceae family or to anthocyanosides may have reactions to bilberry. However, there is a lack of reliable published cases of serious allergic reactions to bilberry.

Side Effects and Warnings

  • Bilberry is generally believed to be safe in recommended doses for short periods of time, based on its history as a foodstuff. There is a lack of known reports of serious toxicity or side effects, although if taken in large doses, there is an increased risk of bleeding, upset stomach, or hydroquinone poisoning.
  • Based on human use, bilberry fresh fruit may cause diarrhea or have a laxative effect. Based on animal studies, bilberry may cause low blood sugar levels. Caution is therefore advised in patients with diabetes or hypoglycemia, and in those taking drugs, herbs, or supplements that affect blood sugar. Serum glucose levels may need to be monitored by a healthcare provider and medication adjustments may be necessary.
  • In theory, bilberry may decrease blood pressure, based on laboratory studies.
  • With the use of bilberry leaf extract, there is a theoretical increased bleeding risk, although there are no reliable published human reports of bleeding. Caution is advised in patients with bleeding disorders, taking drugs that may increase the risk of bleeding, or prior to some surgeries and dental procedures.

Pregnancy and Breastfeeding

  • There is not enough scientific evidence to recommend the safe use of bilberry in pregnancy or breastfeeding, although eating bilberry fruit is believed to be safe based on its history of use as a foodstuff. One study used bilberry extract to treat pregnancy-induced leg swelling (edema), and no adverse effects were reported.

Interactions

Interactions with Drugs

  • Bilberry may lower blood sugar levels, although there is a lack of reliable human studies in this area. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare provider. Medication adjustments may be necessary.
  • Based on human use, bilberry may increase diarrhea when taken with drugs that cause or worsen diarrhea, such as laxatives or some antibiotics. Bilberry theoretically may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®). There are no reliable published human reports of bleeding with the use of bilberry. Based on theory, bilberry may further lower blood pressure when taken with drugs that decrease blood pressure.
  • Based on early laboratory study, berry extracts have been shown to inhibit H. pylori, an ulcer-producing bacteria and enhance the effects of the prescription drug clarithromycin (Biaxin®).
  • Bilberry may also interact with anticancer agents, liver-damaging agents, and estrogen-containing medications. Consult with a qualified healthcare professional, including a pharmacist, to check for interactions.

Interactions with Herbs and Dietary Supplements

  • Based on animal research, bilberry may lower blood sugar levels. Although there is a lack of reliable human study in this area, caution is advised when using herbs or supplements that may also lower blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.
  • Based on theory, bilberry may lower blood pressure further when taken with herbs or supplements that decrease blood pressure.
  • Based on theory, bilberry may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.
  • Based on traditional use, bilberry may increase diarrhea or laxative effects when taken with herbs and supplements that are also believed to have laxative effects.
  • Consuming bilberry with quercetin supplements may result in additive effects. Cooking bilberries with water and sugar to make soup may decrease the amount of quercetin by 40%. Berries contain resveratrol, which has been studied as an antioxidant, for cardiovascular disease, and for cancer and may have additive effects when taken with supplements like grape seed.
  • Bilberry may also interact with anticancer agents, antioxidants, liver-damaging agents, and herbs or supplement with hormonal properties. Consult with a qualified healthcare professional, including a pharmacist, to check for interactions.

Attribution
  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography
  1. Bomser J, Madhavi DL, Singletary K, et al. In vitro anticancer activity of fruit extracts from Vaccinium species. Planta Med 1996;62(3):212-216.
  2. Canter PH, Ernst E. Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials. Surv.Ophthalmol 2004;49(1):38-50.
  3. Erlund I, Marniemi J, Hakala P, et al. Consumption of black currants, lingonberries and bilberries increases serum quercetin concentrations. Eur.J Clin Nutr 2003;57(1):37-42.
  4. Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev 2001;6(2):141-166.
  5. Hou DX. Potential mechanisms of cancer chemoprevention by anthocyanins. Curr Mol Med 2003;3(2):149-159.
  6. Katsube N, Iwashita K, Tsushida T, et al. Induction of apoptosis in cancer cells by Bilberry (Vaccinium myrtillus) and the anthocyanins. J Agric Food Chem 1-1-2003;51(1):68-75.
  7. Kramer JH. Anthocyanosides of Vaccinium myrtillus (bilberry) for night vision--a systematic review of placebo-controlled trials. Surv.Ophthalmol 2004;49(6):618.
  8. Levy Y, Glovinsky Y. The effect of anthocyanosides on night vision. Eye 1998;12 ( Pt 6):967-969.
  9. Logan AC, Wong C. Chronic fatigue syndrome: oxidative stress and dietary modifications. Altern.Med Rev 2001;6(5):450-459.
  10. Lyons MM, Yu C, Toma RB, et al. Resveratrol in raw and baked blueberries and bilberries. J Agric.Food Chem. 9-24-2003;51(20):5867-5870.
  11. Milbury PE, Graf B, Curran-Celentano, JM, et al. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci 2007;48(5):2343-2349.
  12. Muth ER, Laurent JM, Jasper P. The effect of bilberry nutritional supplementation on night visual acuity and contrast sensitivity. Altern Med Rev 2000;5(2):164-173.
  13. Rasetti FRM, Caruso D, Galli G, et al. Extracts of Ginkgo biloba L. leaves and Vaccinium myrtillus L. fruits prevent photo induced oxidation of low density lipoprotein cholesterol. Phytomedicine 1997;3:335-338.
  14. Roy S, Khanna S, Alessio HM. et al. Anti-angiogenic property of edible berries. Free Radic Res 2002;36(9):1023-1031.
  15. Zadok D, Levy Y, Glovinsky Y. The effect of anthocyanosides in a multiple oral dose on night vision. Eye 1999;13 ( Pt 6):734-736.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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