MelatoninMelatonin: Based on human study, melatonin changes after antidepressant use may be due to pharmacological action of these drugs on melatonin secretion (18562432). After treatment with selective serotonin reuptake inhibitors (SSRIs), levels of 6-sulphatoxymelatonin (aMT6s), the main melatonin urinary metabolite, increased. In human trial, fluoxetine reduced melatonin levels (7728363).
SodiumSodium: According to a review, hyponatraemia may be a possible reaction to treatment with selected serotonin reuptake inhibitors (SSRIs) (9742847) and measurement of serum electrolytes may be recommended (9588311), particularly in patients over the age of 65 (9489575).
The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.