Table of Contents > Interactions & Depletions > Arginine Print



Arginine/Nutrient Depletion:
  • Argininosuccinate synthetase (ASS1)Argininosuccinate synthetase (ASS1): In humans, downregulation of ASS1 caused by tumors decreased arginine synthesis and caused arginine auxotrophy (364; 365).
  • Branched-chain amino acidsBranched-chain amino acids: In animals, arginine decreased plasma levels of branched-chain amino acids (287).
  • CholesterolCholesterol: In human research, dietary increases in L-arginine resulted in decreased levels of total cholesterol and triglyceride and increased levels of HDL cholesterol (127; 340; 358).
  • CreatinineCreatinine: In animals, arginine increased plasma creatinine (334).
  • GlucoseGlucose: In diabetic and nondiabetic subjects, L-arginine resulted in improved glucose profiles and fructosamine over exercise alone (106; 127), decreased glucose production (108), improved insulin sensitivity (109), and increased whole-body glucose disposal (111). Plasma glucose increased in one human study (184).
  • SodiumSodium: In humans, use of L-arginine reduced renal sodium excretion with a low salt intake and increased renal excretion with a high salt intake (308; 240).

Copyright © 2011 Natural Standard (

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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