Table of Contents > Interactions & Depletions > Antimalarials Print



Antimalarials/Nutrient Depletion:
  • Vitamin KVitamin K: Based on in vitro evidence, quinines may increase vitamin K requirements (10773499). The authors suggest that if antimalarials are present in patients receiving post-operative vitamin K, vitamin K dosages may be increased to offset a potential donor-acceptor interaction effect.
  • Folic AcidFolic Acid:In vitro evidence suggests that pyrimethamine may have anti-folate activity (19435820, 18831691).
  • L-carnitineL-carnitine: A case report suggests that pyrimethamine may cause carnitine deficiency (8328486). The patient developed a symptomatic L-carnitine deficiency while using pyrimethamine and sulfadiazine, which was reversed upon discontinuation of these agents.
  • RiboflavinRiboflavin:Based on secondary sources, quinacrine and other antimalarial agents may impair riboflavin by inhibiting its conversion into active derivatives.

Copyright © 2011 Natural Standard (

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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