Table of Contents > Interactions & Depletions > Antihypertensives Print



Antihypertensives/Nutrient Depletion:
  • Coenzyme Q10Coenzyme Q10: According to anecdotal reports, clonidine, hydralazine, and methyldopa may reduce CoQ10 concentrations.
  • MelatoninMelatonin: Based on evidence from human and animal studies, medications that reduce levels of vitamin B6 in the body (such as hydralazine) may also deplete melatonin levels (8872867, 11349394, 1806289, 272672).
  • Vitamin B6/pyridoxineVitamin B6/pyridoxine: Based on human case reports, hydralazine (Apresoline®) may increase pyridoxine requirements (5847557). The need for pyridoxine supplementation has not been adequately studied.
  • Zinc:Zinc: Captopril and valsartan have reduced serum zinc levels in rabbits, but not in humans (19198707). This reduction, however, may not be clinically relevant.

Copyright © 2011 Natural Standard (

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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