Table of Contents > Interactions & Depletions > Alpha-lipoic acid (1,2-Dithiolane-3-pentanoic acid) Print

Alpha-lipoic acid (1,2-Dithiolane-3-pentanoic acid)


Alpha-lipoic acid/Nutrient Depletion:
  • Blood glucoseBlood glucose: In human research, effects of alpha-lipoic acid on blood glucose levels and glucose hemostatis were mixed, with decreases or no effects occurring, alone or in combination with antidiabetic agents (8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 88; 20; 21; 22; 23; 24; 25; 26; 27; 28; 29; 89; 90).
  • Blood lipidsBlood lipids: In human research, alpha-lipoic acid has been shown to moderate cholesterol increases associated with use of atypical antipsychotic drugs (107). Improvements in plasma lipids (decreased total cholesterol, LDL cholesterol, and triglycerides, and/or increased HDL cholesterol) occurred in some (82; 118; 13) but not all (19; 17; 20; 27; 96; 126; 28; 30; 29) human studies.
  • ThiamineThiamine: In animal research, thiamine deficiency has been reported with alpha-lipoic acid when taken in high doses (111; 112).
  • Trace elementsTrace elements: An overdose of alpha-lipoic acid has been hypothesized to cause trace element deficiency in those with diabetes mellitus (113).
  • Vitamin CVitamin C: The reduced form of alpha-lipoic acid, DHLA, enhanced recycling of ascorbic acid and vitamin E (204; 205).
  • Vitamin EVitamin E: The reduced form of alpha-lipoic acid, DHLA, enhanced recycling of ascorbic acid and vitamin E (204; 205). However, in human research, alpha-lipoic acid increased alpha-tocopherol plasma concentration (150).

Copyright © 2011 Natural Standard (

The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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