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Chromagic™

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Related terms
Background
Theory/evidence
Safety
Author information
Bibliography

Related Terms
  • Biotin, Brantford and Stratford Herbal Magic®, ChromagicT, chromium, chromium picolinate, Herbal Magic®, vanadium, vitamin B6, WM-2000T.

Background
  • ChromagicT, manufactured by Herbal Magic®, is a dietary supplement that contains chromium, vanadium, biotin, and vitamin B6.
  • According to manufacturer data, ChromagicT is designed to assist in weight loss, proper insulin functioning, and blood sugar regulation. It may also help decrease appetite and sugar cravings, increase muscle mass, regulate cholesterol, and help break down carbohydrates, fats, and protein. However, sufficient evidence on the safety and effectiveness is currently unavailable to make a conclusion on the use of ChromagicT for these indications.
  • Some research is available on the individual ingredients in ChromagicT.

Theory / Evidence
  • General: According to manufacturer data, ChromagicT is designed to assist in weight loss, proper insulin functioning, and blood sugar regulation. It may help decrease appetite and sugar cravings, increase muscle mass, regulate cholesterol, and assist in the breakdown of carbohydrates, fats, and protein. However, available evidence supporting these claims is lacking.
  • Some research is available on the individual ingredients.
  • Chromium: The main ingredient, chromium, is an essential trace element typically found in foods, such as egg yolks, coffee, green beans, nuts, and whole-grain products.
  • Good evidence supports the use of chromium for the treatment of diabetes and high blood sugar levels. It may also help regulate blood sugar levels in patients with low blood sugar disorders. Additionally, chromium picolinate may help improve glucose tolerance in women with polycystic ovary syndrome. However, chromium does not appear to alter hormones.
  • Chromium has also been suggested as beneficial for bipolar disorder, bone loss (in postmenopausal women), heart disease, cognitive function, depression, glucose intolerance, high cholesterol, immune disorders, Parkinson's disease, and schizophrenia. However, research in these areas is unclear or conflicting.
  • Although chromium may help improve lean body mass (by reducing fat and increasing muscle), available evidence suggests that it may not be an effective therapy for obesity.
  • Vanadium: Some research suggests that vanadium may have insulin-mimetic effects. Long-term treatment was shown to decrease blood sugar, triglyceride, and cholesterol levels. However, the potential short and long-term vanadium toxicity has slowed the acceptance of this agent for medicinal use.
  • Vitamin B6: Vitamin B-6 is involved in many bodily functions and is an essential metabolite in humans. Vitamin B-6 is available in many forms, including pryidoxal, pyridoxine, and pyridoxamine.
  • Strong evidence supports the use of vitamin B6 for hereditary sideroblastic anemia, cycloserine side effects, pyridoxine deficiency, and pyridoxine-dependent seizures in newborns.
  • It has also bee suggested as possibly beneficial for akathisia, angioplasty, asthma, attention deficit hyperactivity disorder (ADHD), birth outcomes, cancer prevention, heart disease, carpal tunnel syndrome, depression, hyperkinetic cerebral dysfunction syndrome, immune function, kidney stones, lactation suppression, pregnancy-induced nausea and vomiting, PMS, preventing vitamin B6 deficiency associated with birth control pills, and tardive dyskinesia. However, evidence of effectiveness is unclear or conflicting in these areas.
  • Some evidence suggests that vitamin B6 may aid in carbohydrate, fat, and protein metabolism. Preliminary studies indicate that vitamin B-6 may have antioxidant effects. However, additional research is needed before conclusions can be made in these areas.
  • Available evidence suggests that vitamin B6 may not improve autism or prevent stroke recurrence.
  • Biotin: Biotin is an essential water-soluble B vitamin involved in the break down of lipids and carbohydrates and production of energy. Without biotin, certain enzymes do not work properly, resulting in various complications involving the skin, intestinal tract, and nervous system.
  • Strong evidence supports the use of biotin for biotin deficiency and biotin-responsive inborn errors of metabolism.
  • In early research, biotin has been reported to decrease insulin resistance and improve glucose tolerance, which are both properties that may be beneficial in patients with type 2 diabetes. Evidence suggests that when combined with chromium, biotin may improve glycemic control in overweight type 2 diabetic patients. However, there is not enough human evidence to form a clear conclusion in this area.
  • Biotin has also been suggested as beneficial for brittle fingernails, heart disease, hepatitis (in alcoholics), and pregnancy supplementation. However, evidence is unclear of conflicting in these areas.

Safety




Author information
  • This information has been edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

Bibliography
  1. Albarracin CA, Fuqua BC, Evans JL, Goldfine ID. Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51.
  2. Cefalu WT, Hu FB. Role of chromium in human health and in diabetes. Diabetes Care. 2004 Nov;27(11):2741-51.
  3. ChromagicT product monograph. Herbal Magic® Weight Loss and Nutrition Centers, 2008.
  4. Domingo JL. Vanadium and tungsten derivatives as antidiabetic agents: a review of their toxic effects. Biol Trace Elem Res. 2002 Aug;88(2):97-112. .
  5. Ehrenshaft M, Bilski P, Li MY, et al. A highly conserved sequence is a novel gene involved in de novo vitamin B6 biosynthesis. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9374-8.
  6. Kaats GR, Blum K, Pullin D, and et al. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Current Therapeutic Research 1998;59(6):379-388.
  7. Kaats GR, Blum K, Fisher JA, and et al. Effects of chromium picolinate supplementation on body composition: a randomized, double-masked, placebo-controlled study. Current Therapeutic Research 1996;57(10):747-756.
  8. Katz, SA and Salem, H. The toxicology of chromium with respect to its chemical speciation: a review. J Appl Toxicol 1993;13(3):217-224.
  9. Mao X, Zhang L, Xia Q, et al. Vanadium-enriched chickpea sprout ameliorated hyperglycemia and impaired memory in streptozotocin-induced diabetes rats. Biometals. 2008 Oct;21(5):563-70.
  10. Mertz, W. Chromium in human nutrition: a review. J Nutr. 1993 Apr;123(4):626-33.
  11. Mooney S, Leuendorf JE, Hendrickson C, et al. Vitamin b6: a long known compound of surprising complexity. Molecules 2009 Jan 12;14(1):329-51.
  12. Natural Standard: The Authority on Integrative Medicine. .
  13. Preuss HG, Bagchi D, Bagchi M, et al. Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss. Diabetes Obes Metab. 2004 May;6(3):171-80.
  14. Racek J, Trefil L, Rajdl D, et al. Influence of chromium-enriched yeast on blood glucose and insulin variables, blood lipids, and markers of oxidative stress in subjects with type 2 diabetes mellitus. Biol.Trace Elem.Res. 2006;109(3):215-230.
  15. Raschle T, Arigoni D, Brunisholz R, Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediate. J Biol Chem. 2007 Mar 2;282(9):6098-105. Epub 2006 Dec 21.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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