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Shark cartilage



Interactions

Shark cartilage/Drug Interactions:
  • AnalgesicsAnalgesics: Based on animal studies, shark cartilage has been shown to inhibit nitric oxide synthesis (47; 48).
  • AnestheticsAnesthetics: Based on animal studies, shark cartilage has been shown to inhibit nitric oxide synthesis (47; 48).
  • Antiangiogenic drugsAntiangiogenic drugs: Based on study, patients in treatment protocols involving other antiangiogenic agents should avoid shark cartilage, due to theoretical additive or synergistic activity. Examples include Ag3340, Bay12-9566, Leflunomide, Marimastat, Anti-VEGF antibody, Carboxyaminotriazole, CGS 27023A, AGM-1470, SU5416, Vitaxin, EMD 121974, Interleukin-12, and CM 101 (45).
  • Antiarthritic agentsAntiarthritic agents: In vitro and animal research shows that shark cartilage possesses anti-inflammatory properties (13; 14; 15; 49) and may improve affected joints (50).
  • Antidiabetic agentsAntidiabetic agents: In a phase I/II study using shark cartilage, a patient with type 2 diabetes mellitus and renal carcinoma was noted to develop hypoglycemia (25).
  • Anti inflammatory agentsAnti inflammatory agents: In vitro and animal research has reported that shark cartilage possesses anti-inflammatory properties (31; 13; 14; 15). In animals, shark cartilage was less effective as an anti-inflammatory agent than nitrones (51).
  • CisplatinCisplatin: Based on animal study, shark cartilage may possess antitumor effects (52).
  • Diuretics, thiazideDiuretics, thiazide: Shark cartilage products contain calcium (up to 25%) (28).
  • Gastrointestinal agents, miscellaneousGastrointestinal agents, miscellaneous: Based on human study, shark cartilage may cause gastrointestinal distress (nausea, vomiting, constipation, dyspepsia) (32; 28; 41; 42).
  • Interferons (? and ?)Interferons (? and ?): Based on study, both interferon ? and ? possess antiangiogenic properties and may act synergistically with shark cartilage to inhibit blood vessel growth, slow wound healing, reduce inflammation, or cause birth defects (45).
  • ThalidomideThalidomide: Based on study, thalidomide may act synergistically with shark cartilage to inhibit blood vessel growth, slow wound healing, reduce inflammation, or cause birth defects (53; 45).

Shark cartilage/Herb/Supplement Interactions:
  • AnalgesicsAnalgesics: Based on animal studies, shark cartilage has been shown to inhibit nitric oxide synthesis (47; 48).
  • AnestheticsAnesthetics: Based on animal studies, shark cartilage has been shown to inhibit nitric oxide synthesis (47; 48).
  • Antiangiogenic herbs and supplementsAntiangiogenic herbs and supplements: Based on study, patients in treatment protocols involving other antiangiogenic herbs and supplements should avoid shark cartilage due to theoretical additive or synergistic activity (45).
  • Antiarthritic herbs and supplementsAntiarthritic herbs and supplements: In vitro and animal research shows that shark cartilage possesses anti-inflammatory properties (13; 14; 15; 49) and may improve affected joints (50).
  • Anti inflammatory herbs and supplementsAnti inflammatory herbs and supplements: In vitro and animal research has reported that shark cartilage possesses anti-inflammatory properties (31; 13; 14; 15). In animals, shark cartilage was less effective as an anti-inflammatory agent than nitrones (51).
  • AntineoplasticsAntineoplastics: Based on animal study, shark cartilage may possess antitumor effects (52).
  • AntioxidantsAntioxidants: Ongoing in vitro research has reported that shark cartilage acts as a scavenger for reactive oxygen species (54; 55).
  • Calcium supplementsCalcium supplements: Shark cartilage products contain calcium (up to 25%) (28).
  • Chondroitin sulfateChondroitin sulfate: Chondroitin, a popular therapy for osteoarthritis, is a constituent of shark cartilage.
  • DiureticsDiuretics: Shark cartilage products contain calcium (up to 25%) (28).
  • Gastrointestinal herbs and supplementsGastrointestinal herbs and supplements: Based on human study, shark cartilage may cause gastrointestinal distress (nausea, vomiting, constipation, dyspepsia) (32; 28; 41; 42).
  • Glucosamine sulfateGlucosamine sulfate: Glucosamine, a popular therapy for osteoarthritis, is a constituent of shark cartilage.
  • HypoglycemicsHypoglycemics: In a phase I/II study using shark cartilage, a patient with type 2 diabetes mellitus and renal carcinoma was noted to develop hypoglycemia (25).
  • MineralsMinerals: Trace elements, such as iron, zinc, selenium, copper, manganese, molybdenum, titanium, and strontium, are found in high levels in shark cartilage.

Shark cartilage/Food Interactions:
  • Acidic fruit juices (apple, grape, orange, tomato, cranberry)Acidic fruit juices (apple, grape, orange, tomato, cranberry): Acidic fruit juices may reduce the absorption of shark cartilage (34; 31).

Shark cartilage/Lab interactions:
  • Calcium levelsCalcium levels: Shark cartilage products contain calcium (up to 25%) (28).
  • Keratan sulfateKeratan sulfate: Keratan is a protein measured in basic science research and experimentally as a marker of cartilage metabolism. A protein in shark cartilage reacts with the same antibodies as the keratan sulfate ELISA assay, which may lead to erroneous results (56).
  • Troponin-ITroponin-I: In theory, the troponin-I in shark cartilage may cause a false-positive result in human serum troponin-I assays, a test commonly used to evaluate cardiac ischemia (46). It is unclear, however, if the troponin-I is digested by proteolytic enzymes prior to absorption.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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