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Horseradish (Armoracia rusticana, Cochlearia armoracia)



Interactions

Horseradish/Drug Interactions:
  • AntibioticsAntibiotics: Based on several early in vitro studies and one clinical trial, horseradish may have antibiotic activity (14; 15; 16; 11; 22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an animal study using intravenous horseradish peroxidase, intravenous horseradish may stimulate synthesis of arachidonic acid metabolites (17).
  • AntihypertensivesAntihypertensives: Based on animal study, horseradish in medicinal amounts may have hypotensive activity (18; 17).
  • Anti inflammatory agentsAnti inflammatory agents: Based on an in vitro study, horseradish may inhibit COX-1 enzymes (1; 2).
  • Antineoplastic agentsAntineoplastic agents: Based on in vitro and animal studies, horseradish may have antineoplastic activity (3; 4; 5; 6; 7; 8; 9; 1; 2; 10; 11; 12; 13).
  • AntioxidantsAntioxidants: Based on in vitro study, horseradish root may have oxidative activity (11; 23).
  • Antithyroid agentsAntithyroid agents: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).
  • DiureticsDiuretics: Based on traditional use, horseradish may have strong diuretic effects.
  • Indole-3-acetic acidIndole-3-acetic acid: Based on numerous in vitro studies, horseradish peroxidase may activate indole-3-acetic acid (3; 4; 5; 6; 7; 8).
  • LevothyroxineLevothyroxine: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).

Horseradish/Herb/Supplement Interactions:
  • AntibacterialsAntibacterials: Based on several early in vitro studies and one clinical trial, horseradish may have antibiotic activity (14; 15; 16; 11; 22).
  • Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Based on an animal study using intravenous horseradish peroxidase, intravenous horseradish may stimulate synthesis of arachidonic acid metabolites (17).
  • Anti inflammatory herbsAnti inflammatory herbs: Based on an in vitro study, horseradish may inhibit COX-1 enzymes (1; 2).
  • AntineoplasticsAntineoplastics: Based on in vitro and animal studies, horseradish may have antineoplastic activity (3; 4; 5; 6; 7; 8; 9; 1; 2; 10; 11; 12; 13).
  • AntioxidantsAntioxidants: Based on in vitro study, horseradish root may have oxidative activity (11; 23).
  • DiureticsDiuretics: Based on traditional use, horseradish may have strong diuretic effects.
  • HypotensivesHypotensives: Based on animal study, horseradish in medicinal amounts may have hypotensive activity (18; 17).
  • Indole-3-acetic acidIndole-3-acetic acid: Based on numerous in vitro studies, horseradish peroxidase may activate indole-3-acetic acid (3; 4; 5; 6; 7; 8).
  • Tannin-containing herbsTannin-containing herbs: According to secondary sources, horseradish contains tannins, which may have additive effects when taken with other tannin-containing herbs.
  • Thyroid agentsThyroid agents: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).
  • Vitamin CVitamin C: According to herbal textbooks, horseradish contains a high level of vitamin C.

Horseradish /Food Interactions:
  • Insufficient available evidence.

Horseradish /Lab Interactions:
  • Blood pressureBlood pressure: Based on an animal study, horseradish in medicinal amounts may have hypotensive activity (18; 17).
  • Blood cultureBlood culture: Based on several early in vitro studies and one clinical trial, horseradish may have antibiotic activity (14; 15; 16; 11; 22).
  • Coagulation panelCoagulation panel: Based on an animal study using intravenous horseradish peroxidase, intravenous horseradish may stimulate synthesis of arachidonic acid metabolites (17).
  • Thyroid panelThyroid panel: Based on in vitro evidence, medicinal amounts of horseradish may interact with thyroid medications (20).

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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