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Amylase inhibitors



Interactions

Amylase inhibitors/Drug Interactions:
  • Antidiabetic agentsAntidiabetic agents: In humans, amylase inhibitors may reduce postprandial glucose, C-peptide, and gastric inhibitory polypeptide (19). Thus, there is a potential for interactions between amylase inhibitors and hypoglycemic agents. Amylase-inhibiting drugs, such as acarbose and voglibose, are often used for diabetes (22).
  • Weight loss medicationsWeight loss medications: Preliminary evidence suggests that amylase inhibitors may increase weight loss over dieting alone (4). Thus, there is a potential for interaction between amylase inhibitors and weight loss agents.

Amylase inhibitors/Herb/Supplement Interactions:
  • Garcinia cambogiaGarcinia cambogia: In humans, a combination of amylase inhibitor, inulin, and Garcinia cambogia extract increased weight loss compared with placebo (23).
  • GuarGuar: Guar is a source of soluble and bound amylase inhibitors (14). Thus, there is a potential for interaction if guar and amylase inhibitors are taken at the same time.
  • HypoglycemicsHypoglycemics: In humans, amylase inhibitors may reduce postprandial glucose, C-peptide, and gastric inhibitory polypeptide (19). Thus, there is a potential for interaction between amylase inhibitors and hypoglycemic agents.
  • InulinInulin: In humans, a combination of amylase inhibitor, inulin, and Garcinia cambogia extract increased weight loss compared with placebo (23).
  • Rosmarinic acidRosmarinic acid: Herbal extracts containing rosmarinic acid have been shown to inhibit amylase activity in vitro (24). Theoretically, amylase inhibitors and other plant constituents may have additive effects as well.
  • Weight loss agentsWeight loss agents: Preliminary evidence suggests that amylase inhibitors may increase weight loss over dieting alone (4). Thus, there is a potential for interaction between amylase inhibitors and weight loss agents.

Amylase inhibitors/Food Interactions:
  • Diabetic dietDiabetic diet: In humans, amylase inhibitors may reduce postprandial glucose, C-peptide, and gastric inhibitory polypeptide (19). Thus, there is a potential for interaction between amylase inhibitors and a diet designed for diabetic patients.
  • Dietary carbohydratesDietary carbohydrates: In humans, powdered amylase inhibitor decreased amylase activity by greater than 96% and increased malabsorption of wheat starch (25). Thus, use of amylase inhibitor may decrease absorption of dietary carbohydrates.
  • Dietary fiberDietary fiber: Dietary fiber is a source of soluble and bound amylase inhibitors in guar and other dietary roughage (14). Thus, there is a potential for interaction if dietary fiber and amylase inhibitors are taken at the same time.
  • LegumesLegumes: Legumes are a source of amylase inhibitors (12; 13; 14; 15). Thus, there is a potential for interaction if dietary fiber and amylase inhibitors are taken at the same time.
  • Weight reducing dietWeight reducing diet: Preliminary evidence suggests that amylase inhibitors may increase weight loss over dieting alone (4). Thus, there is a potential for interaction between amylase inhibitors and a diet designed for weight reduction.

Amylase inhibitors/Lab Interactions:
  • C-peptideC-peptide: In humans, amylase inhibitors may reduce postprandial C-peptide (19; 3).
  • Fecal mineralsFecal minerals: In rats, amylase inhibitor increased fecal zinc and copper (26).
  • Gastric inhibitory polypeptideGastric inhibitory polypeptide: In humans, amylase inhibitors may reduce postprandial gastric inhibitory polypeptide (19; 27; 3).
  • InsulinInsulin: In humans, an increase in postprandial insulin was abolished after the use of amylase inhibitors (3). In rats, the use of amylase inhibitors with a starch load had no effect on postprandial insulin levels (20).
  • Peptide YYPeptide YY: In humans, wheat-derived amylase inhibitor increased levels of peptide YY in blood (27).
  • Serum glucoseSerum glucose: In humans, amylase inhibitors may reduce postprandial glucose (19; 27; 3). In rats, the use of amylase inhibitors with a starch load decreased postprandial glycemia (20).

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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