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Agrimony (Agrimonia eupatoria, Agrimonia procera)



Interactions

Agrimony/Drug Interactions:
  • AnticoagulantsAnticoagulants: Due to isocoumarins found in the roots of agrimony (2), there is a possibility that the blood-thinning effect is enhanced if taken with anticoagulants. Theoretically, this may affect the INR level and increase the risk of bleeding. Excessive doses of agrimony can potentiate anticoagulant therapy.
  • Antidiabetic agentsAntidiabetic agents: Since agrimony has been found to demonstrate insulin-like effects in mice (4;5), concurrent use with anti-diabetic agents may theoretically enhance the risk for hypoglycemia. Monitor blood glucose level closely due to claims that agrimony has hypoglycemic effects.
  • Antihypertensive drugsAntihypertensive drugs: Hypotensive effects in anaesthetized cats have been documented for Agrimony extract given by intravenous injection; blood pressure was lowered by more than 40% (1). Therefore, it is possible that the hypotensive effect may be additive with drugs used to treat hypertension. Excessive doses of agrimony might cause hypotension, interfering with therapy for hypertension or hypotension.
  • EstrogensEstrogens: Agrimony may be used to treat symptoms of menopause along with other herbs so it may be likely that it contains estrogenic-like component (6). Therefore, it should not be used in patients on some form of hormone-replacement therapy.
  • Nephrotoxic drugsNephrotoxic drugs: Since agrimony contains up to 21% tannins, chronic ingestion may result in nephrotoxicity.

Agrimony/Herb/Supplement Interactions:
  • AnticoagulantsAnticoagulants: Due to isocoumarins found in the roots of agrimony (2), there is a possibility that the blood-thinning effect is enhanced if taken with anticoagulants. Theoretically, this may affect the INR level and increase the risk of bleeding. Excessive doses of agrimony can potentiate anticoagulant therapy.
  • HypoglycemicsHypoglycemics: Since agrimony has been found to demonstrate insulin-like effects in mice (4;5), concurrent use with antidiabetic agents may theoretically enhance the risk for hypoglycemia. Monitor blood glucose level closely due to claims that agrimony has hypoglycemic effects.
  • HypotensivesHypotensives: Hypotensive effects in anaesthetized cats have been documented for agrimony extract given by intravenous injection; blood pressure was lowered by more than 40% (1). Therefore, it is possible that the hypotensive effect may be additive with drugs used to treat hypertension. Excessive doses of agrimony might cause hypotension, interfering with therapy for hypertension or hypotension.
  • Hormonal herbsHormonal herbs: Agrimony may be used to treat symptoms of menopause along with other herbs so it may be likely that it contains estrogenic-like component (6). Therefore, it should not be used in patients on some form of hormone-replacement therapy.
  • Nephrotoxic herbsNephrotoxic herbs: Since agrimony contains up to 21% tannins, chronic ingestion may result in nephrotoxicity.

Agrimony/Food Interactions:
  • Insufficient available evidence.

Agrimony/Lab Interactions:
  • Coagulation panelCoagulation panel: Due to isocoumarins found in the roots of agrimony (2), there is a possibility that the blood-thinning effect is enhanced if taken with anticoagulants. Theoretically, this may affect the INR level and increase the risk of bleeding. Excessive doses of agrimony can potentiate anticoagulant therapy.
  • Serum glucoseSerum glucose: Since agrimony has been found to demonstrate insulin-like effects in mice (4;5), concurrent use with anti-diabetic agents may theoretically enhance the risk for hypoglycemia. Monitor blood glucose level closely due to claims that agrimony has hypoglycemic effects.

Copyright © 2011 Natural Standard (www.naturalstandard.com)


The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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